Protein Details: Potassium voltage-gated channel subfamily G member 4
Protein ID
ICDB_Pro_1317
Protein Name
Potassium voltage-gated channel subfamily G member 4
Gene Name
KCNG4; KCNG3
Organism
Homo sapiens (Human)
Length
519 amino acids
AlphaFoldDB
AF-Q8TDN1-F1-model_v4.pdb
Function
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1
Sequence
MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM
PDB Structures
Ligand Binding
Binding Site
Disease
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2G and Brown-Vialetto-Van Laere Syndrome 1
Location
Highly expressed in brain; and at lower levels in liver; small intestine and colon.
DOI ID
10.1073/pnas.122617999; 10.1101/gr.2596504; 10.1074/jbc.m808786200
RefSeq
NP_758857.1 [Q8TDN1-1]